Simone Fausto-#ProgressiveSpinalMuscularAtrophy #PSMA The SEVENTH round of treatment: Before treatment: Simone Fausto was present with motor disturbance of limbs and trunk 47 years ago, he went to the local hospital and diagnosed with spinal muscular atrophy. He was able to move his body, write and go to the bathroom himself before 11 years old, but 10 years after that, these abilities were gone. He was not able to hold up his trunk 9 years ago, he need something to support him when he sat. It was difficult for him to chew or swallow, he breathed and coughed hard, when he yelled, his voice was low and unclear. He was not able to move his limbs and trunk 6 years ago, he could hardly control his hear, he had difficult to breathe, chew or swallow, sometimes he chocked and spoke unclear. He comes to our center to have the stem cells treatment every year, after the treatments, his breath was better than before. The neck muscle was powerful, he was able to turn over his heard wider, especially to the right. He was able to open his elbow joints with someone’s help to 120 degrees. Both side fingers could move freely, the thumbs could move inside strongly and he was able to against part resistance. His left thumb and palm could hold a pen together. He took drugs and did the rehabilitation exercise regular. His neck was stronger, he didn’t need neck support anymore. He wanted a better treatment so he came to our hospital. He is in good spirit, his diet, urination and defecation are normal. He put up some weight in one year. Admission PE: Temperature: 37.1℃, Hr: 92/min, Br: 20/min, Bp: 128/80mmHg. There was no pharyngeal congestion. The tonsils were not enlarged. The thorax was not symmetrical. The respiratory sounds in both lungs were clear butslightly lower than normal, with no obvious dry or moist rales. The heart sounds were lower, the cardiac rhythm was regular, with no obvious murmur. The abdomen was distended and soft, sounds liketympany and there wasno palpable mass.His both ankles and feet hadobvious concave edema.His four limbs were shorter than normal. The spinal column was bent to the right side. Both elbow joints and knee joints had contracture and were unable to straighten. The elbow joints could stretch to 85 degree angle passively. The knee joints could stretch to 120 degree angle passively. Nervous System Examination: Simone was conscious and alert. The calculation abilities, insight ability and orientation were normal. His speech was slurred. Both pupils were equal in size and round, the diameter was 3.0mms. Both eyeballs could move flexibly and the pupils reacted normally to light stimulus. There was no obvious nystagmus. The examination of the vision and visual field were normal, he was able to open mouth 1cm, he was able to put his tongue out of mouth about 2 cm. He had no teeth or mouth deflection. He had difficult to chew or swallow and he didn’t need neck support when he was standing. The muscle strength to neck was level 3- when he swivel to the left, the muscle strength of neck was level 3- when heto swivel to the right. The shrug shoulders action could been seen. The muscle strength of both upper limbs’ proximal-end was level 0.When he raised his upper limbs over his head, the left thumb adductor and abductor muscle power was at level 3-, the left index finger was at level 1, the right thumb adductor and abductor muscle power was at level 2,the right index finger was at level 1-2, the muscle power of other fingers were all at level 0. The muscle strength of both lower limbs’ proximal-end was level 0. All toes had slight plantar flexion butdorsi flexion ability was not obvious to see. There was muscle atrophy in all four limbs, shoulder girdle and trunk. The muscle tone of all four limbs was reduced. The abdominal reflexes and tendon reflexes of all four limbs were disappeared. The bilateral palm jaw reflex was negative. The grasping reflex was negative. The bilateral Hoffmann’s sign was negative. The bilateral Babinski’s sign was negative. The sensory examination results were normal. Simone was not able to cooperate with the coordinated movement examination. Treatment: After the admission, he received related examinations and diagnosed with PSMA. He received 4 neural stem cell injections and 4 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation, with rehabilitation training. Post-treatment: After 26 days’ treatment, his breath was better than before, his heart and lung function were stable. His breath sounds of both lungs were clearer than before. He could speak better and clear, he could speak in loud. The muscle power of head and neck are improved to level 3, he could keep head in right position. His upper limbs are flexible, his left wrist bending action could be completed under the specific position. The both hands’ kneading muscle power of thumb and index finger was better than before. He could hold a pen. The muscle power of lower limb was improved, he could move knees, ankles and toes better. His toe could do dorsiflexion and planter flexion. http://www.wumedicalcenter.com/article/PatientStories/sma/142014114884.html

Mr.Allen-Amyotrophic Lateral Sclerosis Anonymous Case Before treatment: In 2015 the patient felt weakness in his left arm. Some days before his right arm had felt weak too. He went to a local hospital many times but he was not diagnosed. His left leg became weak later. He went to hospital again in July 2015 where he did EMG and other tests. He was diagnosed with Amyotrophic Lateral Sclerosis(ALS) and the doctor prescribed Riluzole 50mg, twice a day. His condition wasn’t better and his disease progressed fast. He was then unable to walk 6 months ago, he was unable to speak clearly, he chewed slowly, sometimes he had muscles twitch and he was in pain. He had stomach ache 1 month ago so he stopped taking his medicines. The muscle power of his four limbs decreased and the muscle tension of his four limbs was higher than normal. He is unable to put on clothes or eat by himself. He wanted a better treatment so he came to our hospital. His spirit and diet are good and he sleeps well. His bladder function is normal. He has lost around 5-7 kgs. Admission PE: Bp: 138/83mmHg; Hr: 71/min. Br: 19/min. Body temperature: 36.5 degrees. Tip of the finger blood oxygen was 90-95%. His development was normal and he had good nutrition. There were no yellow stains or petechia on the skin or mucous. Pharyngeal was slightly congested. The tonsils were not enlarged. The thorax was in symmetry but the movement range was reduced. The respiratory sounds in both lungs were normal with no obvious moist or dry rales. The heart sounds were strong, the rhythm of his heartbeat was normal and there was no obvious murmur in the valves. His abdomen was soft and flat. There was no pressing pain or rebound tenderness with no masses. The liver and spleen were normal. Nervous System Examination: Mr.Allen was alert and his spirit was good. He had dysarthrosis. He was not able to speak clearly. His memory, calculation abilities and orientation were normal. Both pupils were equal in size and round, the diameter was 3 mms. Both eyes had sensitive responses to light stimuli. Both eyeballs could move freely. The nasolabial fold and forehead wrinkle pattern were symmetrical. His tongue was centered in the oral cavity and the tongue muscle was not atrophied. There was air leakage when he blew out his cheeks and the power of his chewing was weak. Both soft palates could be raised weakly. The muscles of his bilateral shoulder girdle, upper limbs，bilateral thenar and hypothenar and interosseus of hands were atrophied. His neck was soft，the power to shrug his shoulders was weak. The proximal muscle strength of the left arm was level 1，the distal end muscle strength was level 2-；the proximal muscle strength of the right arm was level 1，the distal end muscle strength was level 2. It was hard for him to stretch his fingers，the grip power of right hand was level 3，the grip power of the left hand was level 2. The muscle power of the legs were level 3-, the muscular tension of his arms were normal，the muscular tension of his legs were increased. The bilateral bicipital muscle reflex and radioperiosteal reflex was slightly down；The lower limbs patellar tendon reflexes and achilles jerk was hyperreflexia. Bilateral palm jaw reflection was positive，bilateral Babinski sign was positive. He could not finish the test of finger to nose and rapid rotation test. The right side heel-knee-tibia test was normal，he could not finish the left side heel-knee-tibia test. The meningeal irritation sign was negative. Treatment: After the admission, he received relevant examinations and was diagnosed with Amyotrophic Lateral Sclerosis. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation This was done along with rehabilitation training. Post-treatment: After 14 days' treatment he could speak clearly, his respiration function is better, the breathing sound of the lower lungs was stronger, the Sat is 95-98%. Both his spirit and energy are improved. The muscle power of the left arm is at level 2. The right arm can lift higher and reach his lower jaw. The muscle power of the right arm is at level 2+, the right hand grip power is increased to level 4. The muscle strength of his legs are at level 4. He is now able to stand up and walk 50 meters. http://www.wumedicalcenter.com/article/PatientStories/als/302017771350.html

James Patrick Eagle-#MacularDegeneration Anonymous Case Before treatment: The patient had some problems with his eyes 12 years ago. He was unable to see if a line was straight or not so he went to local hospital and was diagnosed with Macular Degeneration. His disease became worse and worse and 5 years ago he lost his left eye’s central vision field, he had metamorphopsia, there was a light ring in his right eye and he lost the vision field near his nose with the right eye. He did a test 2 months ago and it was suggested he had higher intracular pressure. He received laser surgery and used Latanoprost eye drops. Since then his intracular pressure became normal. At present he doesn’t have central vision field in left eye, he has metamorphopsia, the vision field near his nose with the right eye is lost, the color vision of both eyes is decreased but his dark vision is normal. He wants a better life so he came to our hospital. His spirit, diet, sleep and weight are all normal, his bladder and bowel functions are normal. Admission PE: Bp: 118/89mmHg; Hr: 52/min, Br: 17/min. His development and nutrition were normal. The skin and mucous was normal. There was no ecchymosis, petechia or yellow stains on skin. The thorax was symmetrical. The respiratory sounds of both lungs were clear, with no moist rales. The heart sounds were strong, the rhythm was regular, and there was no obvious murmur in the valve area. The abdomen was flat and soft with no obvious masses. Through palpation the liver and spleen were not enlarged. Nervous System Examination: He was alert and his speech was clear. His memory, orientation and calculation ability were normal. Both pupils were equal in size and round, the diameter was 2.0 mms. Both eyes were sensitive to direct light reflex and could move freely to each side. There was no nystagmus. The center of the left eye vision was lost, the lost range was about : above 15 cm, below 11 cm, 9 cm on the right side, and 4 cm on the left side. The right eye nasal side visual field defect, on the range of inclined top is about 24 * 18 cm. 3 m standard chart: naked vision of both eyes was 0.5, left eye vision only was 0.5, and right eye vision only was 0.1. Funduscopic examination: right eye fundus’ color was orange, the macular area around 2/3 area boundary was not clear, arteriovenous ratio is 1:3, arteries have sclerosing change. Left eye fundus’ color was orange, the macular area around 4/5 area boundary was not clear, arteriovenous ratio was 1:3. The forehead wrinkle pattern was symmetrical, the nasolabial sulcus was equal in depth, the teeth were symmetrical and the tongue was centered in the oral cavity. There was flexible movement in the neck. The muscle tone of all four limbs was normal and the muscle strength of all four limbs was at level 5. The abdominal reflex was normal. Bilateral biceps reflexes and radioperiosteal reflexes could not be elicited. Bilateral triceps reflexes and patellar tendon reflexes were normal. Bilateral ankle reflexes could not be elicited. The palm jaw reflex was positive. Bilateral Hoffmann sign was negative. The Rossolimo sign was negative. The pathological reflexes of the legs were negative. The deep sensation and superficial sensation were normal. The coordinated movements were normal. The tendon reflexes of the four limbs were normal. The sucking reflex was negative. The Babinski sign was negative. Treatment: After the admission he was diagnosed with Macular Degeneration. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. This was done along with rehabilitation training. Post-treatment: After 14 days treatment his eye vision is getting better, especially his right eye. 3 meters standard visual chart: naked eye vision of both eyes is between 0.5-0.6, left naked eye vision is 0.5, and right naked eye vision is between 0.5-0.6. The defect area of the right eye nasal side visual field is lower than before. Ophthalmoscope examination：The border of both eyes’ macular region is clearer and the defect area shows obvious improvement. www.wumedicalcenter.com/article/PatientStories/Eye-Disorder/212017771349.html

Mr.Kim-#OpticNerve and #RetinaInjury Anonymous Case Before treatment: The patient was unable to see a light ball clearly 20 years ago so he went to a local hospital and was diagnosed with Glaucoma. The doctor prescribed some eye drops to control the problem. The effect was good but his intra-ocular pressure became higher than normal. 5 years ago the eye drops were unable to control it, his vision and central vision field became bad. He had a trabeculectomy 2 years ago and still used eye drops to control intra-ocular pressure but his vision and vision field were not improved. At present he has almost no central vision field and is unable to see objects clearly. He wants a better life so he came to our hospital. His spirit, diet and sleep are all normal. His bladder and bowel functions are normal. Admission PE: Bp: 134/83mmHg; Hr: 80/min, Br: 18/min, body temperature: 36.8 degrees. Height: 182cms, weight: 91kgs. His development and nutrition were normal. The skin and mucous was normal, there was no ecchymosis, petechia or yellow stains on skin. The thorax was symmetrical. The respiratory sounds of both lungs were clear, with no moist rales. The heart sounds were strong, the rhythm was regular and there was no obvious murmur in the valve area. The abdomen was flat and soft with no obvious masses. Through palpation, the liver and spleen were not enlarged. Nervous System Examination: He was alert and his speech was clear. His memory, orientation and calculation ability were normal. Both pupils were equal in size and round, the diameter was 3.0mms. Both eyes were sensitive to direct light reflex and consensual reflex. Eyelids apperture of the left eye was smaller than the right side, conjunctival of the left eye was hyperemia and swelling. 3 m standard chart: corrected vision of both eyes were 0.2, corrected vision of the right eye was 0.08, corrected vision of the left eye was 0.06. 1 m standard chart: naked vision of both eyes were 0.06. 50 cm standard chart: naked vision of both eyes were 0.2, left eye vision only was 0.1, and right eye vision only was 0.1. The central visual field of the both eyes was blurred, the blurred range of the left eye within about 50 cm: above 7 cm, 8 cm on the right side, 19 cm on the left side, the blurred range of the right eye within about 50 cm: above 16.5 cm, below 21.5cm, 15 cm on the right side. Both of his eyes could move to each side but the motion amplitude was poor with no obvious nystagmus. The forehead wrinkle pattern was symmetrical, the nasolabial sulcus was equal in depth, the teeth were symmetrical and the tongue was centered in the oral cavity. There was flexible movement in the neck. The muscle tone of all four limbs was normal; the muscle strength of all four limbs was at level 5. The abdominal reflex was normal. The tendon reflexes of all four limbs were normal. The palm jaw reflex, Bilateral Hoffmann sign, Rossolimo sign and the Babinski sign were all negative. The deep sensation and superficial sensation were normal. The coordinated movements were normal. The sucking reflex was negative. The meningeal irritation sign was negative. Treatment: After the admission Mr.Kim was diagnosed with Optic nerve and retina injury (Post Glaucoma). He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. This was done along with rehabilitation training. Post-treatment: After 14 days of treatment his eye vision is getting better. His field of view lost range is getting smaller than before. 3 meters standard visual chart: corrected vision of both eyes is 0.3, 1 m standard chart: naked vision of both eyes is 0.1. Now he can take care of himself much better. http://www.wumedicalcenter.com/article/PatientStories/Eye-Disorder/212017771348.html

Ms.Sue-#AmyotrophicLateralSclerosis #ALS Anonymous Case Before treatment: The patient's right hand had weakness and atrophy in July 2014. Her condition got worse and in 2016 she had proximal end muscle weakness of the arms. 1 year later her left hand displayed weakness and atrophy. She went to hospital and had an EMG in March 2016 where she was diagnosed with Amyotrophic Lateral Sclerosis (ALS). She did rehabilitation training but her disease did not improve. For now, it is difficult to raise her arms, she is able to walk but slowly and she couldn’t take care of herself well. She wants a better life so she came to our hospital. Her appetite, sleep, swallowing functions and weight are all normal. Her bladder and bowel functions are normal. Admission PE: Bp: 126/83mmHg, Hr: 85/min, breathing rate: 19/min, body temperature: 36.8 degrees, blood oxygen saturation was 94-95%. Nutrition status is normal and she has normal physical development. There is no injury or bleeding spots of her skin and mucosa, no blausucht. Chest develop is normal, the respiratory sounds in both lungs were clear with no dry or moist rales. The heart beat is powerful with regular cardiac rhythm and no obvious murmur in the valves. The abdomen was bulging but with no masses or tenderness. Her liver and spleen were normal, shifting dullness test is negative. There was pitting edema of feet. Nervous System Examination: Patient was alert and her spirit was slightly down. She had clear speech, her memory, orientation and calculation ability were normal. Both pupils were equal in size and round, diameter of 3mm, react well to light and the eyeballs can move freely. No nystagmus. Bilateral forehead wrinkle and nasolabial fold are symmetrical, her tongue is in middle and with no tongue muscle atrophy. She can show her teeth normally but her tongue can not move in a flexible manner. She can bulge her cheeks but with slight weakness, her chewing ability is good and the soft palate can lift powerfully. Her neck muscles are soft, she can move her head freely but the right side is not as strong as normal. Patient can shrug but slightly weaker than normal. Muscle power of proximal upper limbs are 3+ degrees, the distal abductor muscles power is 3 degrees, adductor muscle power is 2 degrees. The grip force of both hands are 4- degrees, the first 3 fingers muscle power are much weaker than ring finger and little finger on both hands. Muscle power of the legs was 4- degrees. Muscle tone of all 4 limbs was normal. Tendon reflex of the arms is lower than normal and of the legs is slightly lower than normal. There was middle degree muscle atrophy of all 4 limbs, Hoffmann sign of both sides are negative; Babinski sign of both sides are negative. She cannot perform finger to nose test as normal. The fast alternate movement of both hands are slow, she can only perform the finger opposite movement with the first 3 fingers. The bilateral Heel-knee-tibia test is slow, Meningeal irritation sign is negative. Treatment: After the admission Ms. Sue received related examinations and was diagnosed with ALS. She received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair her damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate her immune system and improve blood circulation. This was done along with rehabilitation training. Post-treatment: After 14 days' treatment the patient feels that her body movement ability had some positive changes. Her spirit, energy and exercise tolerance were all improved. The muscle power of all four limbs has improved, the grip force of both hands increased to 4 degrees, muscle power of the legs is now 4 degrees. The level of maintaining the blood oxygen concentration was 95-97%. http://www.wumedicalcenter.com/article/PatientStories/als/302017771347.html

Abdulla Mohamed Hassan A Alameeri-#AmyotrophicLateralSclerosis #ALS Before treatment: 1 year ago, patient had no obvious incentive for right hand weakness, the disease gradually progressed, his right upper limb, right lower limb, left lower limb and left upper limb were all has involved, he went to local hospital did the electromyography and other tests, he was diagnosed with " amyotrophic lateral sclerosis". The disease continued to progress, 6 months ago, he could walk with walker, he could do daily work. 3 months ago he began to appear unclear speaking, breathing faster, further declined in motor function, he was unable to take care of himself. He had stem cells treated in Korea in 2016, no improvement after treatment. At present, patients can not stand, walk, stand up, limbs muscles are involved, respiratory function is involved, he could chew, he has occasionally cough. 2 weeks before admission he had lung infection, he was given anti-infective treatment for 5 days, for now he still has cough and sputum. This patient wants for further treatment, so he comes to our hospital. His spirit and sleep are normal. He could only sleep in left lateral position. His diet, urination and defecation functions are normal. He lost 12Kg in one year. He has type 2 diabetes, coronary heart disease, paroxysmal supraventricular tachycardia for many years Admission PE: Bp: 160/90mmHg, Hr: 56/min, breathing rate 22/mim. body temperature: 36.8 degrees. His physical development is normal, nutrition status is fine. There is no injury or bleeding spots of his skin and mucosa, the skin below the ankles were dark red, with lower skin temperature, there was hyperesthesia of the feet, he had die blausucht, there was no congestion of throat, no swelling tonsil. The chest development was symmetrical, breathing sounds of both lungs were weak, especially the lower lungs part, the breathing sounds can be hear when he done deep breath, no obvious dry or moist rales. The heart beat is powerful with regular cardiac rhythm, with no obvious murmur in the valves. Abdomen was flat, there is 20cm scar post surgery of the middle abdomen, touch was soft, no masses or tenderness. His liver and spleen are in normal position, shifting dullness was negative. Vertebral column is normal, there was pitting edema below the ankles, with local skin lower temperature. Arteria dorsalis pedis can be touched, hyperesthesia of the feet skin. Nervous System Examination: Patient was alert and his mental condition is fine, slur speech, the memory, calculation and orientation ability are normal by examination. Both pupils were equal in size and round, diameter as 3.0mm, react well to light, eyeballs can move freely, no nystagmus. Bilateral forehead wrinkle and nasolabial groove are symmetrical, tongue out is normal, tongue muscles can move nearly normal, show teeth is normal. His tongue can touch the cheek powerfully, chewing ability is slightly weak, there is slightly air leakage when he bulge the cheek. Soft plate can lift powerfully, he can close eyes powerfully. Neck is soft, shrug ability was weak, he can turn neck powerfully. The right upper limb distal muscle power is 4- degree; proximal muscle power is 3 degree, left upper limb distal muscle power is 4 degree, proximal muscle power is 3+ degree, right hand grip force is 3- degree, left hand grip force is 3 degree. Lower limbs muscle power is 3- degree. There are obvious muscle atrophy of the bilateral shoulders, upper limbs, hands thenar muscles and lower limbs. Muscle tone decreased. Bilateral biceps reflex and radial periosteal reflex can not be induced by examination, patellar tendon reflex can not be induced, bilateral Palm-jerk reflex is negative, Rossilimo sign of both sides are negative, the left side Hoffmann sign is positive, of right side is negative. Babinski sign of both sides is neutral. Patient can not perform the finger to nose test because of the weakness, he can perform the fast alternate movement clumsy, he can not do the right side finger opposite movement, while his left hand can do the finger opposite movement slowly except the little finger. He can not do the Heel-knee-tibia test, the meningeal irritation sign is negative. Treatment: After the admission, he received related examinations and diagnosed with ALS. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation, with rehabilitation training. Post-treatment: After 14 days’ treatment, he had better exercise tolerance, his respiration functions was improved, his blood oxygen saturation increased to 95-98%, both of his upper limbs were flexible, he could raise arms easier, the right hand grip force can reach 3 degree, the left hand grip force can reach 3+ degree, he can bend the hip and the knees for longer time, his skin in foot is less sensitive. http://www.wumedicalcenter.com/article/PatientStories/als/3020177201351.html

Mr.Lee--#AmyotrophicLateralSclerosis #ALS Anonymous Case Before treatment: The patient had serious pneumonia 2 years ago. It was hard for him to cough and his voice was low and weak. He went to a local hospital and was diagnosed with Amyotrophic Lateral Sclerosis (ALS) and his condition became worse. It was hard for him to speak or swallow and his whole body was weak. He took Riluzole 50mg once a day but his condition wasn’t controlled. He began to have respiration problems and he lost a lot of weight. He began to wear an IV/BiPAP breathing machine in August 2016. He had gastrostomosis surgery in September 2016 then after that he wore a respiration machine all night. There was obvious muscle atrophy. For now, his four limbs are weak and he needs help with eating and dressing. He is able to sit up and stand by himself but slowly, he is able to walk 20-30 steps but his exercise tolerance is bad. He wants a better life so he came to our hospital. His spirit, diet and sleep are all good. His bladder and bowel functions are normal. He has lost around 20 kgs. Admission PE: Bp: 143/99mmHg, Hr: 71/min, breathing rate: 19/min, body temperature: 36 degrees. Height 168cm, weight 50.8Kg. Nutrition status is normal and he has normal physical development. There is no injury or bleeding spots on his skin and mucosa, no blausucht, no throat congestion, and his tonsils do not have swelling. Chest develop is normal but the breathing sound of the lower lungs area is slightly weaker, there was no dry or moist rales. The heart beat is powerful with regular cardiac rhythm and with no obvious murmur in the valves. The abdomen was soft, with no masses or tenderness. The liver and spleen were normal, shifting dullness test is negative. The spinal column is normal, there was no edema in either leg. Sat is 90-95%. Nervous System Examination: Patient was alert and mental status was good but he cannot speak. The memory, orientation and calculation ability were normal . Both pupils were equal in size and round, diameter of 3mm, react well to light and the eyeballs can move freely. No nystagmus. Bilateral forehead wrinkle and nasolabial fold are symmetrical, his tongue is in middle, with tongue muscle atrophy. The tongue cannot move freely especially in the vertical direction. Showing of the teeth is normal. Patient cannot bulge his cheeks powerfully, his chewing ability is poor and the soft palate cannot lift powerfully. Pharyngeal reflex is weak but the patient can close his eyes as normal. There is obvious muscle atrophy in the bilateral shoulders, arms and bilateral thenar muscles. The neck is soft and he can turn his head and shrug powerfully. Muscle power of the left arm：adduction abductor muscles of upper arm is 4- degrees; forearm flexor muscle power is 3 degrees, extensor muscle power is 3+ degrees, grip force of the left hand is 4- degrees. Muscle power of right arm: adduction abductor muscles of upper arm is 4- degrees; forearm flexor muscle power is 3 degrees, extensor muscle power is 3+ degrees, grip force of the left hand is 4 degrees. Muscle power of the legs is 4 degrees. All 4 limbs muscle tone is normal and the ankle clonus is negative. The bilateral bicipital tendon reflex, radial periosteal reflex, patellar tendon reflex and Achilles tendon reflex can not be induced by examination. The palm-jerk reflex of both sides are positive, the Hoffmann sign of both sides are negative, bilateral Babinski sign is negative, finger to nose test and the fast alternate movement are clumsy The finger opposite movement of the left side is clumsy, right side is much better. Heel-knee-tibia test is basically normal. Meningeal irritation sign is negative. Treatment: After the admission he received related examinations and was diagnosed with ALS. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. This was done with rehabilitation training. Post-treatment: After 15 days treatment his breathing function is better, the oxyhemoglobin saturation increased to 95-97%, movement endurance increased, muscle strength of the four limbs is stronger than before, he can stand independently and his gait is better than before. Muscle power of the arms is better, his left upper arm can lift higher, the finger-finger test of the left hand is better, the right hand grip is now at level 5-. Both his spirit and energy have improved. He is now able to walk longer, around 30-50 meters. http://www.wumedicalcenter.com/article/PatientStories/als/302017771346.html

Mr.Moore-#AmyotrophicLateralSclerosis #ALS Anonymous Case Before treatment: Mr.Moore felt down in May 2015. His hindbrain felt down to ground, he was in a coma and taken to hospital. When he woke up, his left hand was weak, it was hard for him to swallow and to speak. The examination result showed his cervical spine was damaged so he was diagnosed with cervical spondylopathy of the spinal cord. In July he had surgery and after that his hand was a little more powerful and he could speak and swallow normally. But he felt his arms had become weak again, there was fascicular twitching, his left shoulder was painful and the condition became worse. In October 2015, his legs were weak, his balance function was bad, it was hard for him to chew or swallow and he couldn’t speak clearly. He was diagnosed with Amyotrophic Lateral Sclerosis in November 2015 in Israel. He took Riluzole for 6 months without any improvement. His disease became worse, and in March 2016 he could walk only with a walker. He had examinations in Moscow in June and it found that lead level in his blood was much higher than normal. At present he is unable to eat, put on clothes, sit up, stand up or walk. He chokes when eats a liquid diet or drinks water. He is unable to speak clearly and he wants a better life so he came to our hospital. His spirit is normal. He eats liquid food. He sleeps well. His bladder and bowel actions are normal. He has lost 8 Kgs. Admission PE: Bp: 127/80mmHg, Hr: 78/min, breathing rate: 19/mim, body temperature: 36.5 degrees, height: 184cm, weight: 95kg. Nutrition status is normal with normal physical development. There is no injury or bleeding spots of his skin and mucosa, no blausucht. There is a little throat congestion and his tonsils do not have swelling. Chest develop is normal, thoracic mobility abated, the respiratory sounds in both lungs are low, there is no dry or moist rales. The heart beat is powerful, with no obvious murmur in the valves. The abdomen is flat, with no masses or tenderness. His liver and spleen are normal, there is edema in both legs, skin temperature is normal, fluctuations of dorsalis pedis artery are normal. Nervous System Examination: Patient is alert and his spirit is good. He has dysarthria. His speech is unclear. His memory, orientation and calculation ability are normal. Both pupils are equal in size and round, diameter is 3mm, react well to light, eyeballs can move freely. No nystagmus. Bilateral forehead wrinkle and nasolabial fold are symmetrical, his tongue is in middle, with mild tongue muscle atrophy and fibrillation. His tongue can reach the lip only. Movement of the tongue muscle is limited and his tongue can not touch the cheek. Showing teeth is normal. Patient can bulge his cheek but with air leakage and his chewing ability is weak. Bilateral supraspinatus, infraspinatus muscles, both arms muscles, bilateral thenar muscles, hypothenar muscles and interosseous muscles in the both hands are atrophied. His neck muscles are soft, his head movement and shrug power are weak. His right arm muscle strength is at level 5-, the left arm muscle strength is at level 5, both his hands grip strength is at level 4, both legs muscle strength is at level 3 and the four limbs’ muscle tension is high. The tendon reflex of the four limbs is overactive. Bilateral Hoffmann sign of both sides are negative, the Babinski signs are positive. His both hands cannot finish the finger to nose test, the fast alternative test and finger to finger test, because of the low muscle force. Meningeal irritation sign is negative. Treatment: After the admission he was diagnosed with Amyotrophic lateral sclerosis. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged motor nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. This was done along with rehabilitation training. Post-treatment: After 14 days of treatment movement function of all limbs was better than before with increased muscle strength. The muscle strength in the legs increased 1 level. His spirit and energy were better. http://www.wumedicalcenter.com/article/PatientStories/als/3020176131345.html

Moshe Ashkenazi-#AmyotrophicLateralSclerosis #ALS Before treatment: Moshe Ashkenazi found his right leg was weak 1 year ago. It was hard to walk, but he was not concerned. Then his left leg and arms became weak. Six months ago his leg functions were bad and he fell over a lot. He went to a local hospital and was diagnosed with ALS. The doctor prescribed Riluzole and he also did rehabilitation training but his disease became worse again. In the last two months he has been confined to bed. His limbs were stiff and weak, he was unable to move them well and he couldn’t take care of himself. He wants a better life so he came to our hospital. His appetite and spirit are good but he couldn’t sleep well. His urination function is normal, he uses medicines to help him with defecation once in 2 days. He has had hypertension for many years but it is controlled well. Admission PE: Bp: 106/83mmHg; Hr: 113/min. Br: 18/min. Body temperature: 36.2 degrees. His development was normal and he had good nutrition. There were no yellow stains or petechia on the skin or mucous. The thorax was in symmetry. The respiratory sounds in both lungs were clear, with no obvious moist or dry rales. The heart sound was strong and the rhythm of his heartbeat was normal. There was no obvious murmur in the valves. His abdomen was bulging. There was no pressing pain or rebound tenderness with no masses. The liver and spleen were normal. Shifting dullness was negative. There were pitting edema below his ankles， Nervous System Examination: Moshe Ashkenazi was alert and his spirit was good. He had dysarthrosis and he was not able to speak clearly. His memory, calculation abilities and orientation were normal. Both pupils were equal in size and round, the diameter was 3 mms. Both eyes had sensitive responses to light stimuli and both eyeballs could move freely. There was no nystagmus. The nasolabial fold and forehead wrinkle pattern were symmetrical. His tongue was centered in the oral cavity and the tongue muscle was not atrophied. The teeth were shown without deflection. The flexibility of the tongue muscle was not very good. He was able to do cheek blowing well. His chewing was normal. Both soft palates could be raised and the uvula was normal. His neck was soft，he could turn his neck in a flexible and powerful way but the power of shrugging his shoulders was weak. His bilateral shoulder joint，elbow joints and metacarpophalangeal joints were limited，his elbow joint stayed at a bending position. The muscle power of his arms were level 1+，his hand grip was limited. The general movement ability was limited. The muscle power of his legs were level 1，the muscle tone of his legs was high，especially the abduction. The bending tension was high and the four limbs tendon reflexes were slightly higher than normal. The muscles of the four limbs were moderately atrophied. The bilateral Hoffmann sign was negative. The bilateral Babinski sign was positive. He could not finish the movement of finger to nose test and rapid rotation test. He could only do the thumb to index finger of his right hand and the others could not finish the test. He could not finish the heel-knee-tibia test. The meningeal irritation sign was negative. Treatment: After the admission, he was diagnosed with Amyotrophic lateral sclerosis. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged motor nerves, replace dead nerves with new injected stem cells, nourish nerves and improve blood circulation. This was done with rehabilitation training. Post-treatment: During 14 days’ treatment his breathing function and heart function was more stable. The muscle tension of his four limbs obviously reduced. The muscle power and movements of his limbs are better. The metacarpophalangeal joints of both hands are more relaxed and the pain of his joints is in remission. The grip power of both hands has reached level 3-, the muscle power of his legs is 2-. His spirit and energy are increased. http://www.wumedicalcenter.com/article/PatientStories/als/3020176131344.html

Danila Mayorchik-#BattenDisease Anonymous Case Before treatment: The patient was normal when he was born. He was able to say “papa” and ”mama” at 12 months, he was able to walk at 15 months, he was the same as normal kids up to 3 years old. His motor functions and diet were normal, only his speaking ability was delayed. He could only speak 10 words at the age of 3 years and he was unable to say a whole sentence. On January 2nd, 2016 he had a spasm and was diagnosed with epilepsy. He was prescribed some medicines but his condition became worse, his motor function was bad, and he had seizures in the last year that would last 6-7 minutes. When he had a seizure he lost consciousness and when he woke up he cried a lot. The longest seizure lasted for 12 minutes and most of time they occurred just before sleep and after waking up. He was diagnosed with Batten disease CLN2 type after a gene test and his medicines were changed. After 3 weeks his condition was stable and his motor function was a little better, but his intelligence condition and speaking ability were bad. He could only speak about 10 words though his comprehension ability was normal. He used gestures to express his feelings and get what he wanted such as “hungry” or “pee”. He was able to stand up, sit up and turn over by himself but he needed help to walk. He was able to grasp objects but his fine motor movement was bad. His parents wanted a better life for him so they came to our hospital. His spirit, diet and sleep are normal. Admission PE: Bp: 95/58mmHg, Hr: 96/min, body temperature: 37 degrees. Height: 110cms, weight: 17kgs. His physical condition was normal and his nutritional status was good. The skin and mucosa were normal, with no yellow stains or petechia. Oropharynx was not congestive. His bony thorax was symmetrical. The respiratory sounds in both lungs were normal, there was no dry or moist rales. The heart sounds were strong. The cardiac rhythm was regular, with no obvious murmur in the valves. The abdomen was flat and soft, with no masses or tenderness. His liver and spleen were normal. Shifting dullness was negative. Spinal column was normal. There was no edema in either leg. Nervous System Examination: The patient was alert and his spirit was good. He could not complete the memory, orientation and calculation ability examination. His understanding is basically normal. He can perform the simple orders but has language retardation,. He can say "mom and dad" and so on but with 10 words only. He expresses his needs through gestures. He could not complete the examination of vision and hearing. Both pupils were equal in size and round, the diameter was 2.5mm. Both pupils react well to light stimulus. His eyesight is normal with no diplopia and both eye fields were normal. The forehead wrinkles were symmetrical. Bilateral nasolabial sulcus was equal in depth. He could not complete the examination of teeth and tongue showing or muscle power but his muscular tension is normal. He can walk slowly with help, he can sit down and stand up, stand alone and turn over on the bed independently. Large joint movement of both arms are normal, hands fine motor is poor, his hand can grasp toys or objects etc. but he can't use a spoon to eat. Tendon reflex of the arms is normal. Tendon reflex of the legs is active, and abdomen reflex is normal. Sucking reflex is negative, Hoffmann sign of both sides are negative, Babinski sign is positive, bilateral ankle clonus is positive. He could not complete the examination of sensation examination and coordinate movement. Meningeal irritation sign was negative. Treatment: After the admission he received related examinations and was diagnosed with Batten disease. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. This was done along with rehabilitation training. Post-treatment: After 13 days’ treatment, his speed of walking was faster, step pitch was better, he can stand by himself for 90 seconds. http://www.wumedicalcenter.com/article/PatientStories/bd/2620176131343.html

21 September–World Alzheimer’s Day #WAD World Alzheimer’s Day, September 21st of each year, is a day on which Alzheimer’s organizations around the world concentrate their efforts on raising awareness about Alzheimer’s and dementia. Alzheimer’s disease is the most common form of dementia, a group of disorders that impairs mental functioning. http://www.wumedicalcenter.com/article/Treatment/52013112466.html

Ms. Patinkin-#ParkinsonDisease #PD Anonymous Case Before treatment: The patient felt stiffness in her left shoulder 5 years ago but she didn’t care about it too much. After that her left arm became stiff and she was unable to move it well. She was diagnosed with Parkinson's disease by a local hospital and she took some medicines but the effect was not very high. Her condition became worse, she was unable to walk well and her walking position was abnormal. She spoke faster, was unable to write well, had pain in her legs and back and couldn’t sleep well managing just 4-6 hours each day. She takes Levodopa 125mg, twice a day, Rasagiline 1mg, once a day, Pramipexole 3mg once a day. She is able to take care of herself but her movement is slow and her balance function is bad so she came to our hospital. Her appetite is normal, she is unable to sleep well, her urination and defecation abilities are normal. Admission PE: Bp: 126/84mmHg, Hr: 75/min. Breathing sounds of both lungs are clear with no dry or moist rales. The heart beat is powerful with regular cardiac rhythm and no obvious murmur in the valves. The abdomen was bulging and soft but with no masses or tenderness. Liver and spleen are in the normal position and there is no edema of the legs. Nervous System Examination: Patient was alert but her facial expression was reduced. Speech was clear but rapid. Her memory, orientation and calculation ability were normal. Both pupils were equal in size and round, diameter as 3.0mm, react well to light, eyeballs can move freely. Her tongue is in the middle with no tremor. The bilateral soft palate lift is normal and the uvula is in normal position. She can shrug her left shoulder slowly, muscle power of left arm is 5-, the right arm is 5 degrees. Muscle power of the legs is 5 degrees. Muscle tone of the 4 limbs is normal and tendon reflex is normal. Abdominal reflex is normal, the bilateral Hoffmann signs are negative, Rossilimo signs are negative, sucking reflex of both sides is negative, the bilateral Palm-jerk reflex is negative. Babinski sign of the left side is a doubtful positive, the deep and superficial sensitivity are normal. Fingers to nose test, fingers opposite test and fast alternate movement are basically normal. Patient can perform the Heel-knee-tibia test in a stable manner but slowly, she has an abnormal gait when she is walking. This is a festinating gait and she had bad balance control when she wants to turn around. The Romberg's sign is negative, the Meningeal irritation sign is negative. Treatment: After the admission the patient received a detailed medical examination and was diagnosed as 1.Parkinson disease 2. Chronic thyroiditis. She received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair her damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate her immune system and improve blood circulation, This was done along with rehabilitation training. Post-treatment: After 5 days’ treatment, her back pain has reduced and her night sleep is better. The four limbs are more flexible. Her balance has improved and she is now able to turn around in a normal manner. Both her energy and spirit are better and her exercise tolerance is much better. http://www.wumedicalcenter.com/article/PatientStories/pd/3520176131342.html