Blackburn Cathedral is one of England's newest cathedrals, yet it is one of the country's oldest places of Christian worship. With the creation of the Diocese of Blackburn in 1926 (taken from the Diocese of Manchester) the impressive parish church of St Mary the Virgin was raised to cathedral status. The church, which was built in 1826 and designed by architect John Palmer, now forms the cathedral's nave.

In the early 1930s, fundraising began to enlarge the cathedral so that the building complemented its newfound importance. By 1938, enough money had been raised and work began on enlarging the new cathedral. Although work was interrupted by the war, it was resumed afterwards and continued through the 1950s and into the early 1960s. After the death of architect W.A. Forsyth in 1950, architect Laurence King joined the project and designed the distinctive lantern tower. The lantern tower, which consists of 56 different panes of coloured glass and an aluminium spire, was completed in 1967.

The cathedral was finally completed in 1977 and what had been built over the past decades was finally consecrated as Blackburn Cathedral.

The North transept contains eight misericords dating from the 15th century. It is not known at what time they arrived at the Cathedral, but they are believed to have originated at Whalley Abbey. This could mean that they were removed to a builder's yard after the Dissolution, but with the cathedral not being built until the 19th century, this allows for the possibility that they had lain unused for some 300 years.